How it works: 1
- Bupropion SR was the first non-nicotine medication shown to be effective for smoking cessation.
- Its possible mechanisms of action include blockade of neuronal re-uptake of dopamine and norepinephrine and blockade of nicotinic acetylcholinergic receptors.
- Its recommended use is to begin taking it 1-2 weeks before quitting smoking and can be used for long term therapy up to 6 months post quitting.
What the evidence says:
- Strength of Evidence: A The Clinical Practice Guide states that Bupropion SR is, “appropriate as a first-line medication for treating tobacco use” with precautions for pregnant women and is contraindicated for individuals who have a history of seizures or eating disorders, who are taking another form of bupropion, or who have used an MAO inhibitor in the last 14 days (DHHS, 2008, p. 47).
- Quitting Rates
- Research studies have found Bupropion SR to help achieve safe and effective sustained smoking reduction over time. Studies have reported up to a 27% success quit rate of smoking compared to placebo in clinical trials. 2
Possible Side Effects:
- Dry mouth
Where to get it:
- Bupropion SR is available through prescription only.
- Commercial brands include:
- Wellbutrin SR and Zyban
- Fiore, M. C., Jaen, C. R., Baker, T. B., & al., e. (2008). Treating Tobacco Use and Dependence 2008 Update. Clinical Practice Guideline. In U.S. Department of Health and Human Services (Ed.). Rockville, MD: U.S. Department of Health and Human Services.
- Simon, J. A., Duncan, C., Huggins, J., Solkowitz, S., & Carmody, T. P. (2009). Sustained-release bupropion for hospital-based smoking cessation: A randomized trial. Nicotine & Tobacco Research, 11(6), 663-669.